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ACTA VULNOLOGICA

A Journal on Physiopathology and Therapy of Chronic Cutaneous Ulcers


Official Journal of the Italian Association for Cutaneous Ulcers
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Acta Vulnologica 2008 June;6(2):63-8

Copyright © 2008 EDIZIONI MINERVA MEDICA

language: Italian

Cutaneous ulcers treatment with platelet gel

Mancini S., Bucalossi M., Gazzabin L., Mancini S.

Centro di Ricerca, Terapia e Riabilitazione Flebolinfologia Dipartimento di Chirurgia Università di Siena, Siena, Italia


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Aim. We evaluate the effectiveness of platelet gel in the leg ulcers treatment.
Methods. From November 2003 up to now we treated, at the Phlebo-lymphological Centre of the University of Siena, total of 76 ulcers belonging to 43 patients. These cases were divided in two groups. Group 1 of “resistant” lesions: 44 ulcers of 33 patients (33 female – 8 male); Group 2 of “new” lesions treated firstly with platelet gel: 32 ulcers of 20 patients (12 female – 8 male). Ulcers etiology was multiple: 16 varicose, 7 ulcers from Deep Venous Thrombosis (DVT), 4 arterial, 27 mixed, 7 traumatic, 10 diabetic, 1 from bone infection and 4 amputation stumps. We valued pain with the Visual Analogic Scale (VAS). A weekly implantation directly in the wound were performed after surgical debridment, with a platelet concentration of 1.2 milions/mL. In all case, except one, we use homologous platelet gel.
Results. We considered result after 4 consecutive implantations. There was a drop out before of this limit in 8 ulcers of group 1 and 2 of group 2. All the remaining lesions showed an improvement in both groups. Healing registrered in Group 1 was 79.1%, while in Group 2 was 100%, excluding subsequent drop-out. VAS demonstrated an improvement passing in Group 1 from a mean of 8.24 to 6.48 and in Group 2 from a mean of 6.87 to 1.76.
Conclusion. Platelet gel showed to be efficacy in the treatment of all type of ulcers, with an evident improvement after four consecutive graft.

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