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A Journal on Physiopathology and Therapy of Chronic Cutaneous Ulcers
Official Journal of the Italian Association for Cutaneous Ulcers
Indexed/Abstracted in: EMBASE, Scopus, Emerging Sources Citation Index
Acta Vulnologica 2008 June;6(2):63-8
Cutaneous ulcers treatment with platelet gel
Mancini S., Bucalossi M., Gazzabin L., Mancini S.
Centro di Ricerca, Terapia e Riabilitazione Flebolinfologia Dipartimento di Chirurgia Università di Siena, Siena, Italia
Aim. We evaluate the effectiveness of platelet gel in the leg ulcers treatment.
Methods. From November 2003 up to now we treated, at the Phlebo-lymphological Centre of the University of Siena, total of 76 ulcers belonging to 43 patients. These cases were divided in two groups. Group 1 of “resistant” lesions: 44 ulcers of 33 patients (33 female – 8 male); Group 2 of “new” lesions treated firstly with platelet gel: 32 ulcers of 20 patients (12 female – 8 male). Ulcers etiology was multiple: 16 varicose, 7 ulcers from Deep Venous Thrombosis (DVT), 4 arterial, 27 mixed, 7 traumatic, 10 diabetic, 1 from bone infection and 4 amputation stumps. We valued pain with the Visual Analogic Scale (VAS). A weekly implantation directly in the wound were performed after surgical debridment, with a platelet concentration of 1.2 milions/mL. In all case, except one, we use homologous platelet gel.
Results. We considered result after 4 consecutive implantations. There was a drop out before of this limit in 8 ulcers of group 1 and 2 of group 2. All the remaining lesions showed an improvement in both groups. Healing registrered in Group 1 was 79.1%, while in Group 2 was 100%, excluding subsequent drop-out. VAS demonstrated an improvement passing in Group 1 from a mean of 8.24 to 6.48 and in Group 2 from a mean of 6.87 to 1.76.
Conclusion. Platelet gel showed to be efficacy in the treatment of all type of ulcers, with an evident improvement after four consecutive graft.