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A Journal on Physiopathology and Therapy of Chronic Cutaneous Ulcers
Official Journal of the Italian Association for Cutaneous Ulcers
Indexed/Abstracted in: EMBASE, Scopus, Emerging Sources Citation Index
Acta Vulnologica 2008 March;6(1):25-30
Platelet gel: evaluation of its role in wound bed preparation and clinical-qualitative analisis
Ponzio I., Pierangeli M., Marchesini A., Carboni A., Talevi D., Grassetti L., Petrucci E., Bertani A., Scalise A.
Unità Operativa Complessa di Chirurgia Plastica e Ricostruttiva Università Politecnica delle Marche, Ancona
Aim. Platelet gel is a topical adjuvant treatment, used in surgical and clinical area. Platelet derivatives lack evidence, so that its use cannot be justified and regulated. The present study derives from the collaboration among the Univer-sities of Ancona, Pietra Ligure and L’Aquila. This is a multicenter, randomized and controlled study. Aims of the study were to find the minimal effective platelet concentration; to discover the most clinically efficient platelet product; to make a comparison with the traditional treatment.
Methods. All the patients, belonging to different etiological classes, were enrolled simultaneously in the three centers. They were treated with autologous or omologous platelet gel, produced by the same methodology. A sample of the gel was used to quantify the contents of three growth factors: PDGF, VEGF and TGF-β.
Results. Thanks to the growth factors contents, analized during the study, the wounds recover faster than normal, independently on wound etiology and patient’s age or clinical condition.
Conclusion. The unification of the methodologies, together with the aim achieving, can guarantee product quality, use of the gel and patient monitoring. The methodology could possibly be standardized.