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A Journal on Physiopathology and Therapy of Chronic Cutaneous Ulcers

Official Journal of the Italian Association for Cutaneous Ulcers
Indexed/Abstracted in: EMBASE, Scopus, Emerging Sources Citation Index




Acta Vulnologica 2008 March;6(1):19-24

language: Italian

Tissue engineering in plastic surgery. A clinical review after 10 years of methodology application

Pierangeli M. 1, Astolfi M. 1, Marazzi M. 2, Ponzio I. 1, Bertani A. 1, Scalise A. 1

1 Unità Operativa Complessa di Chirurgia Plastica e Ricostruttiva Università Politecnico delle Marche, Ancona
2 Struttura Semplice di Terapia Tissutale Ospedale Niguarda, Ca’ Granda, Milano


Bioengineering shows an innovative and rivolutionary way of action, that combines engineering’s functions, like design and building, to biology. Tissue engineering is a field of bioengineering, geared to make biological substitutive that could maintain, re-establish or improve tissue structure and functions. Tissue engineering represents a new approach to reconstruction and repair of tissue and organ damaged by a pathology, a trauma or by genetic defects. Advantages derived from the use of human tissue produced with a coltural in vitro system, are: safety and effective of the product, material availability. Skin was the first completely engineered organ. Engineering passed from the experimental phase to the treatment phase on humans. It was used to treat burst, cutaneous ulcers and wounds of different depth. In the last 10 years, at the Department of Plastic and Reconstructive Surgery of Ancona, 177 patients divided into 12 etiological groups were treated with autologous graft made with bioengineered fibroblasts and keratinocytes. In this article are described the draft treatment inclusion standards, the recovery percentage and the time required for wound to completely cover.

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