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A Journal on Physiopathology and Therapy of Chronic Cutaneous Ulcers

Official Journal of the Italian Association for Cutaneous Ulcers
Indexed/Abstracted in: EMBASE, Scopus, Emerging Sources Citation Index




Acta Vulnologica 2007 March;5(1):13-7

language: Italian

Assessment of the efficacy and tolerability of stabilized hydrogen peroxide 1% cream in the reduction of bacterial presence in venous leg ulcers

Romanelli M., Semeraro R. M., Barbanera S., Dini V., Bertone M. S., Brilli C.

Clinica Dermatologica Università degli Studi di Pisa, Pisa


Bacterial presence is a major problem in the management of wound healing. The growth of pathogenic microorganisms negatively impacts on the healing process because it increases the risk of infection and causes delays or even arrests the progression of the wound healing phases. The aim of the study is to evaluate efficacy and local tolerability of 1% hydrogen peroxide cream (Crystacide®) cream in patients with colonized venous leg ulcers in comparison with treatment with silver sulfadiazine cream. The results showed a significant better control on wound colonization, evaluated by means of quantitative microbiological test. Patients experienced faster healing and better control on pain when treated with hydrogen peroxide compared to control group. The use of topical antiseptics for a specific time during tissue repair in chronic wounds is a safe and effective procedure, which could be suggested in different type of lesions.

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