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Official Journal of the Italian Association for Cutaneous Ulcers
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Acta Vulnologica 2006 March;4(1):9-14

language: Italian

Tissue engineering and leg ulcers

Dini V., Romanelli M.

Sezione Riparazione Tessutale Cutanea Clinica Dermatologica Università degli Studi di Pisa, Pisa


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The integrity of the skin should be restored as soon as possible whenever the skin gets wounded. Increased research and understanding of acute and chronic wounds has led to the development of new therapies to stimulate and improve healing of difficult wounds. This article provides an overview of the latest theories and technology in wound healing field. Skin substitutes provide a new technological ap-proach to wound healing with hope for the future management of both acute and chronic wounds. Skin substitutes prepared from cultured skin cells reduce requirements for donor skin autograft for closure of full-thickness cutaneous wounds, and demonstrate qualitative outcome. These new technologies improve patient’s quality of life and offer reductions in morbidity and mortality for the treatment of burns and chronic wounds, and for cutaneous reconstruction.

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