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A Journal on Physiopathology and Therapy of Chronic Cutaneous Ulcers
Official Journal of the Italian Association for Cutaneous Ulcers
Indexed/Abstracted in: EMBASE, Scopus, Emerging Sources Citation Index
Acta Vulnologica 2005 December;3(3-4):111-5
Aminoacids and wound bed: a possible interaction for a topic and general treatment in the chronic skin lesions repair
Cassino R., Ricci E.
Vulnera - Centro Vulnologico Italiano, Torino
Aim. It is a lot of years that we all know that there is a strong binding between proteins availability and tissue repair. Proteins are very important to achieve wound healing because they constitute the fibroplastic and proliferative phase. If our body needs proteins that it builds using aminoacids which are derived from foods we eat, why don't we put aminoacids directly on the wounds, just because that micromoleculas can be adsorbed locally? Can we consider the local aminoacids use just like a topic treatment very closed to a general therapy? If our body needs a proteic support to built the tissue loss where there is a chronic skin lesion, we thought that it would be possible to give the basic elements to the wound directly.
Methods. We used an aminoacidic powder, mixed with a few jaluronic acid quantity, as a wound dressing; there were no preferences about secondary dressing (a moist gauze or an antimicrobial one) because we highlighted no statistically significant differences. We recruited chronic skin lesions with different aetiologies and we excluded necrotic and/or infected wounds. Then, we evaluated effectiveness of the treatment, weartime, comfort and adverse reactions.
Results. The treatment showed real effectiveness, a good weartime and a few number of adverse reactions. The comfort was quite good. We have to remark the high absorption rate of the aminoacidic powder and the debriding action due to the hypertonic effect of the dressing.
Conclusion. Topic treatment is not so effective than general therapy, but, maybe, we found something useful in both kind of treatment: a topic therapy with a ''like-general'' effect, maybe a new frontier in the approach to a patient with chronic ulcers.