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A Journal on Physiopathology and Therapy of Chronic Cutaneous Ulcers

Official Journal of the Italian Association for Cutaneous Ulcers
Indexed/Abstracted in: EMBASE, Scopus, Emerging Sources Citation Index




Acta Vulnologica 2005 March;3(1):45-8

language: Italian

Use of heterologous collagen in spray formulations: Biospray

Crespi A. 1, Martinoli M. 2, Ferrari A. 3, Lombardi A. 4

1 Dipartimento di Chirurgia Generale ASL 13 Novara
2 Dipartimento di Chirurgia Generale ASL 13 Novara
3 Ambulatorio Lesioni Cutanee P.O. San Rocco – Galliate – ASL 13 Novara
4 Servizio Cure Domiciliari di Novara ASL 13 Novara


Aim. The aim of this article was to show that it is possible to obtain an improvement in the clinical picture of a non-healing skin lesion by using heterologous collagen in a spray formulation.
Methods. Eight patients for a total of 9 vascular ulcers of the lower extremities of varying aetiology dating back at least 6 weeks with little or no tendency to cure, were followed up for 2 months. Heterologous collagen in spray form was used and medication was changed every other day.
Results. The spray collagen demonstrated a high cure level.
Conclusions. Handy and easy to use, the spray collagen is effective especially in lesions that present little exudate.

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