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A Journal on Physiopathology and Therapy of Chronic Cutaneous Ulcers

Official Journal of the Italian Association for Cutaneous Ulcers
Indexed/Abstracted in: EMBASE, Scopus, Emerging Sources Citation Index




Acta Vulnologica 2004 June;2(1-2):13-6

language: Italian

Platelet gel and chronic cutaneous ulcer

Pestarino R. 1, Cavalieri M. 1, D’Agosta A. G. 2, Panunzio V. 2, Farris A. 1

1 U.O.C. di Dermatologia
2 Servizio di Immunoematologia e Trasfusionale Ospedale S. Paolo, ASL2 Savona


Growth factors involved in tissue repair process are numerous. In physiological conditions plate­let-derived growth factor (PDGF) promotes macrophages chemotaxis, stimulates granulation tissue, regulates remodelling of newly formed tissue. On contrary in chronic wounds is well proved a lack of growth factors due to increased degradation and/or inactivation and to reduced production. For these reasons we started a collaboration between Dermatology and Transfusion departments for the treatment of cutaneous chronic ulcers using a platelet gel, autologous or homologous. The blood from the patient is treated with two centrifugations, the first at low rounds, the second at high speed. From first centrifugation a rich in plate­lets serum is obtained, with the second a serum poor in platelets. This second serum is cryo-precipitated. At the moment of use the two serums are mixed together and form a kind of gel that is easily modelled in the bed of the ulcer and left, after a simple bendage, tree days. With this method 21 patients have been treated up to day, all with stuck chronic ulcers, with full resolution. The only secondary effect referred by some of the patients was a slight burning in the first 12-24 hours.

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