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A Journal on Physiopathology and Therapy of Chronic Cutaneous Ulcers
Official Journal of the Italian Association for Cutaneous Ulcers
Indexed/Abstracted in: EMBASE, Scopus, Emerging Sources Citation Index
Acta Vulnologica 2003 August;1(1):37-42
Treatment of hard-to-heal vascular ulcers by mean of allograft
Mosti G., Mattaliano V., Iabichella M. L., Picerni P.
Reparto di Angiologia e Cardiologia, Clinica MD Barbantini, Lucca
AIM: Vascular ulcers non-responsive to previously proved effectiveness treatment (moist dressings, elastic bandage, walking) can be submitted to skin graft. Recently, allografts, so far restricted to burn care, are used in vascular refractory ulcers. Personal experience in the treatment of “hard-to-heal” ulcers with allograft is reported.
METHODS: A total of 100 patients (30 males; 70 females) age 75.7±10.6 years with 271 vascular ulcers were treated; ulcers area was 154.2±192.5 cm2 (from 1 to 1000); ulcer duration was months 31±55.7 (from 1 to 300) and were resistant to previous good medical treatment. Graft was repeated in 47 patients so that 194 procedures were performed; in 180 cases cryo-preserved in 14 cases glycerolate preserved skin was grafted.
RESULTS: During the follow-up, 57 patients healed in 114.2±69 days; out of 43 patients non-healed, 36 improved, 5 remained unchanged, 2 worsened; pain disappeared in 76 patients, reduced in 22 and unchanged in 2; exudate ceased in 56 patients, reduced in 43, unchanged in 1. Local infection was observed in 1 case.
CONCLUSION: Allograft is effective in promoting healing or improvement of vascular ulcers; it is also effective in pain and exudate control; last but not least this treatment is safe and not expensive.