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A Journal on Physiopathology and Therapy of Chronic Cutaneous Ulcers
Official Journal of the Italian Association for Cutaneous Ulcers
Indexed/Abstracted in: EMBASE, Scopus, Emerging Sources Citation Index
Acta Vulnologica 2003 August;1(1):9-19
Istituto Dermopatico Immacolata, IRCCS, Roma
Cutaneous vasculitis include a wide and heterogeneous group of diseases characterized by specific inflammatory changes of venules, arterioles and capillaries. A pathogenetic role of circulating immunecomplexes and autoantibodies in these syndromes is diffusely accepted. Small vessel vasculitis can be limited to the skin or represent the cutaneous involvement in the case of systemic vasculitis. The skin is a preferential target organ and the result is the clinical feature of palpable purpura and the histological changes of leukocytoclastic vasculitis. The occlusion or narrowing of the cutaneous vessels is a frequent complication. It explains the focal ischemia and the consequent skin ulcer. It has been calculated that approimately 5-8% of the ulcers may be substained by a vasculitic disorder. Thus, the new term “microangiopathic ulcer” includes a large part of cutaneous vasculitis which may manifest or complicate with cutaneous ulcers.