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A Journal on Physiopathology and Therapy of Chronic Cutaneous Ulcers
Official Journal of the Italian Association for Cutaneous Ulcers
Indexed/Abstracted in: EMBASE, Scopus, Emerging Sources Citation Index
Acta Vulnologica 2003 April;1(0):11-7
Photodynamic therapy in wound healing
Mastronicola D., Romanelli M.
Clinica Dermatologica, Università degli Studi di Pisa, Pisa
AIM: Photodynamic therapy (PDT) is a new and effective treatment modality for many forms of localised malignant diseases and various non-malignant cutaneous disorders. PDT involves the activation of photosensitising agent by visible light to produce activated oxygen species which promote biologic effects as modulation of inflammatory reaction and antimicrobial action.
METHODS: The potential benefit of topical PDT in a wound animal model has been investigated. A cutaneous wound was obtained in Sprague-Dawley rats by intradermic injection of doxorubicin. The treatment was delivered as follow: Group A: control (no PDT); Group B: single PDT treatment on day 10; Group A1: control (no PDT); Group B1: treatment on day 10-20-30.
RESULTS: A significantly different healing rate was observed in group B compared to control, particularly in the 5 days following PDT treatment (p=0.0001). Repetitive treatments in Group B1 resulted in a statistically significative reduction of total healing time.
CONCLUSION: The faster healing time in PDT treated wounds could be due to the induction of an inflammatory infiltrate and to the control of microbial load in the wound bed.