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A Journal on Phlebology
Acta Phlebologica 2015 August;16(2):77-81
The acute effect of the antioxidant drug “U-74389G” on platelet-crit levels during hypoxia reoxygenation injury in rats
Tsompos C. 1, Panoulis C. 2, Toutouzas K. 3, Zografos G. 3, Papalois A. 4
1 Department of Obstetrics and Gynecology, Mesologi County Hospital, Etoloakarnania, Greece;
2 Department of Obstetrics and Gynecology, Aretaieion Hospital, Athens University, Attiki, Greece;
3 Department of Surgery, Ippokrateion General Hospital, Athens University, Attiki, Greece;
4 Exprerimental Research Center ELPEN Pharmaceuticals, S.A. Inc., Co., Attiki, Greece
AIM: The aim of this experimental study was to examine the effect of the antioxidant drug “U-74389G”, on rat model and particularly in an hypoxia-reoxygenation protocol. The beneficial effect or non-effectiveness of that molecule were studied hematologically using blood mean platelet-crit (pct) levels.
METHODS: Forty rats of mean weight 231.875 g were used in the study. Pct levels were measured at 60 min of reoxygenation (groups A and C) and at 120 min of reoxygenation (groups B and D), A and B without but C and D with U-74389G administration.
RESULTS: U-74389G administration non-significantly increased the pct levels by 9.23±6.29% (P=0.1064). Reoxygenation time non-significantly increased the pct levels by 3.76±6.44% (P=0.4803). However, U-74389G administration and reoxygenation time together non-significantly increased the pct levels by 6.72±3.73% (P=0.0712).
CONCLUSION: U-74389G administration wheter it interacted or not with reperfusion time, did not increase pct levels significantly in the short-term. Perhaps, a longer study time may result in significant alterations.