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Frequency: 3 issues
Online ISSN 1827-1766
Gasbarro V. 1, 2, Amato B. 1, 3, Izzo M. 1, Manfrini A. 2, Buffone G. 4, Grande R. 4, Serra R. 1-4, De Franciscis S. 1-4
1 Interuniversity Center of Phlebolymphology Magna Grecia University Località Germaneto, Catanzaro, Italy;
2 Department of Vascular Surgery University of Ferrara, Ferrara, Italy;
3 Department of General, Geriatric Oncologic Surgery and Advanced Technologies “Federico II” University of Naples, Naples, Italy;
4 Department of Medical and Surgical Science Magna Grecia University Località Germaneto, Catanzaro, Italy
Aim: Venous leg ulceration is a fearsome complication of chronic venous disease and it accounts for important socio-economical problems in western countries. The scope of this study is to evaluate a new tool which includes the use of Compression Therapy together with topical application of Quercetin compounds in order to improve wound healing in venous ulcers.
Methods: Patients eligible for the study were of both sexes, older than 20 years with chronic venous leg ulcer, evidence of venous reflux at duplex scanning, with an ankle-brachial pressure index >0.9. in order to receive compression therapy and/or surgical treatment (basic treatment) and local Quercetin administration. Patients were randomized in two groups: group A: 44 subjects, were treated with basic treatment + local quercetin administration for a six year period. Group B: 29 subjects were treated with basic treatment only for a six year period. Clinical evalutation, Duplex Ultrasound, Elastosonography and photographic evalutation were performed every 15 days for the first 180 days. Median follow-up was 15 months for group A and 13 months for group B.
Results: Group A: 24 patients out of 44 (45% of the study sample) reported an improvement recorded at clinical and instrumental evaluations (P<0.01) where only in 7 patients out of 29 (31.03%) of Group B this improvement was recorded.
Conclusion: Compression therapy associated with a quercetin slow releasing “under stocking” system showed good clinical results in treating patients with chronic venous ulceration of the lower limbs.