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A Journal on Phlebology
Acta Phlebologica 2010 April;11(1):5-10
Patients with chronic venous disease-related symptoms without signs: prevalence and hypotheses on pathophysiology
Allegra C., Antignani P. L.
Department of Angiology, San Giovanni Hospital, Rome, Italy
Chronic venous diseases (CVD) involve those patients who present with so-called symptoms and/or signs of venous disease which characterize each clinical class of CVD in the CEAP classification, from class C0 to class C6. The symptoms traditionally ascribed to CVD include aching, heaviness, a feeling of swelling, cramps, itching, tingling, and restless legs. The C0s clinical class of the CEAP classification takes into account those patients who present with CVD-related symptoms but without visible signs. Despite the acknowledgment of this profile of patients in a worldwide accepted classification, their prevalence has not been clearly assessed in epidemiological surveys. In Italy the topic has interested several groups of researchers since the 1980s and there has been attempts to explain the pathophysiology of such condition. It seems that this might happen because of risk factors and through hemodynamic changes in venous flow with the appearance of initial signs of reflux. This has been thus considered as a prevaricose syndrome with functional disturbances in which both microcirculatory stasis and hormonal troubles coexist.