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Online ISSN 1827-1766
Department of Internal Medicine “A” Haemek Medical Center, Afula, Israel
The natural history of deep venous thrombosis (DVT) is a dynamic process, with both thrombolysis and thrombus extension occurring after an episode of DVT. Pulmonary embolism (PE) remains the main immediate complication of deep vein thrombosis (DVT) and is associated with a high mortality rate. The postthrombotic syndrome (PTS), on the other hand, is the most harmful consequence of venous thrombosis on the long term and the major cause of increased morbidity and disability during follow-up. Several recent clinical studies have investigated and shed light on the natural history of DVT and the importance that recanalization of the thrombus and venous reflux have in preserving normal venous function . Knowledge of the evolution of these processes could result in better understanding of PST and be applied for improvement of medical and surgical management of venous thrombosis and its complications. These and other debated issues associated with PTS are reviewed here.