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A Journal on Phlebology

Official Journal of the Italian College of Phlebology
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Acta Phlebologica 2006 August;7(2):39-44


language: English

Mechanism of disease: the inflammatory chain in chronic venous disorders and genetic screening for prevention of venous leg ulcers

Lanzara S., Catozzi L., De Palma M., Federici F., Palazzo A., Tacconi G., Gianesini S., Singh A. V., Zamboni P.

Department of Surgery Vascular Diseases Center University of Ferrara, Ferrara, Italy


The inflammatory chain following venous outflow obstruction/reflux, and consequent microcirculatory overload, can be nowadays considered practically deciphered. Tissue drainage becomes insufficient because venous hypertension influences trans-mural pressure (TMP). Increased TMP determines expression of adhesion molecules on the endothelial cells, promotes red blood cells extra-vasation and either dermal hemosiderin deposits or iron laden-phagocites. Iron plays a role in the pathogenesis of venous leg ulcers: local iron overload may generate free radicals or activates a proteolytic hyperactivity of metalloproteinases (MMPs) or else down regulate tissue inhibitors of MMPs. These negative effects are particularly evident in carriers of the common HFE gene’s mutations C282Y and H63D, because intracellular iron deposits of mutated macrophages have less stability than those of the wild type, inducing a significant oxidative stress. It has been proven that these mutations increase the risk of ulcers and advance the age of ulcer onset, respectively. The inflammatory iron-dependent chain in CVD paves the way to new therapeutic strategy including the deliberate induction of iron deficiency as a treatment modality for non healing and/or recurrent venous leg ulcers. In addition, relatives of ulcers patients, carriers of the HFE mutation, when affected by CVD could undergo to genetic screening followed by a prevention program of venous leg ulcers.

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