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Official Journal of the Italian College of Phlebology
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Acta Phlebologica 2005 December;6(3):137-44

language: English

Allograft in wound healing: uncommon uses

Mosti G., Iabichella M. L., Picerni P., Magliaro A., Mattaliano V.

Reparto di Angiologia e Cardiologia, Clinica M.D. Barbantini, Centro Studi “Città di Lucca”, Lucca


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After having experienced allograft in hard-to-heal leg vascular ulcers with good results we tried to treat, with this method, ulcers with particular features: exposed bones or tendons, undermining, fistulas. Nine patients affected by leg ulcers with such features were included in this study; after having prepared the ulcer bed with moist dressing and we used the allograft as a biological plug filling with it large tissue loss, undermining, fistulas. Staples or stitch weren’t used and the graft was fixed to the ulcer bed by dressing with non-adhesive gauze and bandaging the affected leg. Pain and exudate, when present, were dramatically decreased or stopped by the procedure. All the patients healed in 11.3 weeks (range from 4 to 34). The allograft, transforming an open wound in a closed one, induces a well documented antiseptic action and represents an effective stimulus for the neovascularization and the keratinocytes migration from the wound edge. Moreover the allograft, entrapped in the wound could act as a support matrix for the colonization by host cells; adverse effects were not noticed.
This method could be an effective treatment in selected cases of wounds with unusual features.

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