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A Journal on Phlebology
Acta Phlebologica 2004 December;5(2-3):31-5
Coagulation status in patients with deep vein thrombosis of the lower extremities
Milic D., Zivic S., Stojiljkovic M., Pejic M., Karanikolic A.
Department of Vascular Surgery, Surgical Clinic, University Clinical Centre Nis, Serbia, Serbia and Montenegro, Yugoslavia
AIM: Venous thromboembolism is a relevant social and health care problem for its high incidence, pulmonary embolism-related mortality, and long-term sequelae which may be disabling (post-thrombotic syndrome and ulceration). The aim of our work was to establish the presence of coagulation disorders in patients with deep vein thrombosis of the lower extremities.
METHODS: Prospectively we have analyzed a group of 78 patients with echosonographically verified deep vein thrombosis of the lower extremities who were admitted and treated at our institution from August 1st, 2001 to July 31st, 2003. The following coagulation parameters were monitored: prothrombin time (PT), partial thromboplastin time (PTT), fibrinogen (Fib), α-2 antiplasmin (A-2AP), D-dimer (DD), antithrombin III (AT III) and factor VII.
RESULTS: Activation of the coagulation process was registered in 72 out of 78 (92.3%) patients examined with deep vein thrombosis of the leg. Plasma levels of monitored parameters in the patients with DVT of the leg were significantly higher than in the control subjects. D-dimer was the most sensitive parameter monitored in this study and increased values of D-dimer were present in 70 out of 78 patients examined (89.74%).
CONCLUSION: The results obtained in this study undoubtedly indicate the importance of routine examination of coagulation status in patients with suspected deep vein thrombosis of the lower extremities.