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A Journal on Phlebology

Official Journal of the Italian College of Phlebology
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Acta Phlebologica 2002 December;3(3):117-23

language: English

Quality of ­life of ­patients ­with chron­ic ­venous insuf­fi­cien­cy. Impact of med­i­cal treat­ment

Lozano F. S. 1, Jiménez-Cossio J. A. 2

1 Vascular Surgery Department, Salamanca Hospital, Salamanca, Spain;
2 Vascular Surgery Department, “La Paz” Hospital, Madrid, Spain


AIM: In ­order to ­assess the effi­ca­cy of a ­drug in the treat­ment of chron­ic ­venous insuf­fi­cien­cy (CVI), it is impor­tant to eval­u­ate not ­only the symp­toms and ­signs asso­ciat­ed ­with the dis­or­der but ­also the evo­lu­tion of the ­patient’s qual­ity of ­life. The ­CIVIQ qual­ity of ­life ques­tion­naire (val­i­dat­ed in Spanish ­after its French orig­i­nal) is a use­ful ­tool to ­assess ­patient’s respons­es to treat­ment ­both in prac­tice and in clin­i­cal ­trials.
METHODS: Open, pros­pec­tive, epi­dem­i­olog­i­cal clin­i­cal ­trial in mul­ti­ple cen­tres. A ­total of 482 ­patients ­with CVI (­CEAP 0-4) ­were includ­ed. After a ­wash-out peri­od, ­they ­were treat­ed ­with a micron­ized flav­o­noid (Daflon 500, 2 cap/day) for 6 ­months. The fol­low­ing param­e­ters ­were ana­lyzed in fol­low-up vis­its ­held ­after 60, 120 and 180 ­days: clin­i­cal symp­toms (­pain on a vis­u­al ana­logue ­scale, swell­ing, weighti­ness and ­cramp), ­calf perim­e­ter (Leg-O-Meter®) and qual­ity of ­life (­CIVIQ ques­tion­naire).
RESULTS: The ­drug ­used (Daflon 500 for 6 ­months) ­improved all of the symp­toms meas­ured (p<0.001), ­reduced the malle­o­lar perim­e­ter (p<0.001) and ­increased the qual­ity of ­life of ­these ­patients (p<0.001).
CONCLUSION: At the end of the ­study, the qual­ity of ­life had ­increased by 10.3 ­points (­from 66.4±18.5 to 76.7±18.2).

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