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A Journal on Phlebology
Acta Phlebologica 2001 April;2(1):43-9
language: English, Italian
Postsclerotherapy occurrance of hyperpigmentation and other local and systemical signs in the treatment of small vessels varices with different sclerotherapic agents. Preliminary report
Santoro P. 1, Blandamura M. 1, Chiti D. 2, Scaramuzzino L. 3
1 Clinica Angiomedica - Roma;
2 Ambulatorio Angiologico - Prato (Firenze);
3 Università degli Studi - Catanzaro, Scuola di Specializzazione in Chirurgia Vascolare, AO NA1 Ospedale Loreto Mare
BACKGROUND: To determine the safety of a short term use of purified sodium tetradecyl sulphate in form of water solution or foam obtained according to Tessari’s method in the treatment of small vessels varices.
METHODS: One hundred and two patients of which 18 male and 84 female of about 38 middle age were treated for 3 months with 3 different sclerosant agents purified sodium tetradecyl sulphate, chromated glycerin, pholidocanol in telangiectases and reticular veins. Each patient received 8 sclerotherapic treatments and the 3 sclerosant agents were used in form of water solution or foam beginning from known concentrations and diluted at desired concentrations using a water 2% solution of carbocaine or physiologic solution.
RESULTS: In all the patients treated with the three different sclerosant agents, there were not isolated signs of eschara; there were 2 cases of early hyperpigmentations (2% of the cases treated) with the use of purified sodium tetradecyl sulphate, 4 cases (3.9% of the cases treated) with the use of chromated glycerin and 5 cases (4.9%) with the use of pholidocanol; there were isolated 2 cases (2%) of local signs of allergy with the use of purified sodium tetradecyl sulphate, 6 cases (5.9%) with the use of chromated glycerin and 8 cases (6.8%) with the use of pholidocanol; the patient’s compliance was good in 97 cases (95.1%) with the use of purified sodium tetradecyl sulphate and good in 92 cases (90.2%) with the use of both chromated glycerin and pholidocanol. Finally, cases of hypersensitivity and systemically allergy signs (anaphylaxis) associated with the use of these three different sclerosants were not observed.
CONCLUSIONS: Sodium purified tetradecyl sulphate has shown to be a sclerosant agent with a high safety index in the treatment of small vessels varices both in water solution or foam, especially for the incidence of cutaneous signs of esthetical interest (early hyperpigmentation and telangiectatic matting, local allergic signs) and for the patient’s compliance compared with the most employed and safe sclerosant agents actually available in therapy. The use of foam can also highly reduce the concentration and the volume of the sclerosing drug to use, so that the incidence of local signs of inflammation, eschar, pain after treatment and hyper pigmentations is lower.