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A Journal on Phlebology
Acta Phlebologica 2000 December;1(2):87-91
Physiological tissue changes after administration of micronized Diosmin/Hesperidin, individually or in association with Endermologiae
Lattarulo P. 1, Bacci P. A. 2, Mangini S. 3
1 Neurophysiological Service, Hospital Policlinico di Monza, Monza, Italy;
2 Leg’s Aesthetic Pathologies Center, Privat Hospital S. Chiara, Florence, Italy;
3 School and Surgery Institute, University of Siena, Siena, Italy
BACKGROUND: Despite the individual use of Endermologie and Diosmin/Hesperidin producing active physiological changes in the cutaneous microcirculation, the possibility of using individual treatments in association has never been taken into consideration. In the cutis treated with Endermologie, microcirculatory changes concern the increase of the blood and lymphatic flow; this effect is no doubt linked to the mechanical stimulation of the cutis and of the subcutis through the contemporary action of positive pressure, suction and the mechanical massage operated by rollers.
METHODS: The study was carried out with Optical Probe Videocapillaroscopy (OPVC), Laser Doppler Flow measurements and transcutaneous Oxymetry on 34 subjects, 20 females and 14 males, after having informed them and obtained their consent; their ages ranged from 18 to 42 (average of 30). The phlebotonical drug used is a phlebotropic and venoprotective drug whose active ingredients are micronized. Diosmin/ Hesperidin.
RESULTS: Molecular activities on microcirculation are conducted through various mechanisms that go from reduction of blood viscosity and capillary permeability to an increase in tcpO2 and the capillary blood flow with reduction of stasis and of anti-inflammatory activity. The data we obtained after Videocapillaroscopic measurements indicate that capillary blood flow rate values and an increase in capillary density virtually overlap both after Endermologie and after intake of 4 tablets of the phebotonical drug as compared to initial values. After associating the two therapeutic methods, values appear to be almost doubled.
CONCLUSION: To conclude, the data that we found unquestionably reveals greater combined treatment efficacy in terms of an increase in microcirculatory parameters; the mechanical action of Endermologie, which in our opinion must also be studied neurologically, is more efficacious with the intake of micronized Diosmin/Hesperidin.