Home > Journals > Acta Phlebologica > Past Issues > Acta Phlebologica 2000 December;1(2) > Acta Phlebologica 2000 December;1(2):87-91





A Journal on Phlebology

Official Journal of the Italian College of Phlebology
Indexed/Abstracted in: EMBASE, Scopus, Emerging Sources Citation Index




Acta Phlebologica 2000 December;1(2):87-91


language: English

Physiological tissue changes after administration of micronized Diosmin/Hesperidin, individually or in association with Endermologiae

Lattarulo P. 1, Bacci P. A. 2, Mangini S. 3

1 Neurophysiological Service, Hospital Policlinico di Monza, Monza, Italy; 2 Leg’s Aesthetic Pathologies Center, Privat Hospital S. Chiara, Florence, Italy; 3 School and Surgery Institute, University of Siena, Siena, Italy


BACKGROUND: Despite the indi­vid­u­al use of Endermologie and Diosmin/Hesperidin pro­duc­ing ­active phys­io­log­i­cal chang­es in the cuta­ne­ous micro­cir­cu­la­tion, the pos­sibil­ity of ­using indi­vid­u­al treat­ments in asso­ci­a­tion has nev­er ­been tak­en ­into con­sid­er­a­tion. In the cut­is treat­ed ­with Endermologie, micro­cir­cu­la­to­ry chang­es con­cern the ­increase of the ­blood and lym­phat­ic ­flow; ­this ­effect is no ­doubt ­linked to the mechan­i­cal stim­u­la­tion of the cut­is and of the sub­cut­is ­through the con­tem­po­rary ­action of pos­i­tive pres­sure, suc­tion and the mechan­i­cal mas­sage oper­at­ed by roll­ers.
METHODS: The ­study was car­ried out ­with Optical Probe Videocapillaroscopy (­OPVC), Laser Doppler Flow meas­ure­ments and trans­cu­ta­ne­ous Oxymetry on 34 sub­jects, 20 ­females and 14 ­males, ­after hav­ing ­informed ­them and ­obtained ­their con­sent; ­their ­ages ­ranged ­from 18 to 42 (aver­age of 30). The phleb­o­ton­i­cal ­drug ­used is a phleb­o­trop­ic and venop­ro­tec­tive ­drug ­whose ­active ingre­dients are micron­ized. Diosmin/ Hesperidin.
RESULTS: Molecular activ­ities on micro­cir­cu­la­tion are con­duct­ed ­through var­i­ous mech­a­nisms ­that go ­from reduc­tion of ­blood vis­cos­ity and cap­il­lary perme­abil­ity to an ­increase in tcpO2 and the cap­il­lary ­blood ­flow ­with reduc­tion of sta­sis and of ­anti-inflam­ma­to­ry activ­ity. The ­data we ­obtained ­after Videocapillaroscopic meas­ure­ments indi­cate ­that cap­il­lary ­blood ­flow ­rate val­ues and an ­increase in cap­il­lary den­sity vir­tu­al­ly over­lap ­both ­after Endermologie and ­after ­intake of 4 tab­lets of the pheb­o­ton­i­cal ­drug as com­pared to ­initial val­ues. After asso­ciat­ing the two ther­a­peu­tic meth­ods, val­ues ­appear to be ­almost dou­bled.
CONCLUSION: To con­clude, the ­data ­that we ­found unques­tion­ably ­reveals great­er com­bined treat­ment effi­ca­cy in ­terms of an ­increase in micro­cir­cu­la­to­ry param­e­ters; the mechan­i­cal ­action of Endermologie, ­which in our opin­ion ­must ­also be stud­ied neu­ro­log­i­cal­ly, is ­more effi­ca­cious ­with the ­intake of micron­ized Diosmin/Hesperidin.

top of page

Publication History

Cite this article as

Corresponding author e-mail